Tumor-specific immunotherapy based on dominant models of natural tolerance

E. Montero, J. F. Amador, R. Pérez, A. Lage

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

9 Citas (Scopus)


The assumption that cancer immunotherapy may be based on the existence of autoreactive lymphocytes recognizing self-antigens on cancer cells, obviously opens a new opportunity. Nevertheless this analysis, relying on a recessive model of natural tolerance, limits the approach to try to activate peripheral lymphocytes, by increasing costimulatory signals or using modified self-antigens for immunization. Here we hypothesize that, based on emerging dominant tolerance notions in autoimmunity, it would be possible to induce a specific autoimmunity against tumor cells and arrest their growth following the removal of regulatory T cells. These immunoregulatory cells suppress available immunocompetent autoreactive cells capable of destroying tumor cells. Therefore, in order to reach a complete tumor-specific autoimmunity it is necessary to combine the T cell immunosuppression which abrogates the regulatory cells, with the cancer vaccines, which induces extensive proliferation of lymphoid cells directed towards specificities on tumor cells. (C) 2000 Harcourt Publishers Ltd.

Idioma originalInglés
Páginas (desde-hasta)531-536
Número de páginas6
PublicaciónMedical Hypotheses
EstadoPublicada - abr. 2000
Publicado de forma externa


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