Topical anti-inflammatory activity of human recombinant epidermal growth factor

A. Casacó Parada; N. Ledón; A. González; N. Merino; R. Pérez

doi:10.1159/000029848

Topical anti-inflammatory activity of human recombinant epidermal growth factor

A. Casacó Parada
, N. Ledón
, A. González
, N. Merino
, R. Pérez

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

10 Citas (Scopus)

Resumen

The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-O-tetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 μg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.

Idioma original	Inglés
Páginas (desde-hasta)	79-84
Número de páginas	6
Publicación	Skin Pharmacology and Applied Skin Physiology
Volumen	12
N.º	1-2
DOI	https://doi.org/10.1159/000029848
Estado	Publicada - 1999
Publicado de forma externa	Sí

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title = "Topical anti-inflammatory activity of human recombinant epidermal growth factor",

abstract = "The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-O-tetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 μg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.",

keywords = "12-O-tetradecanoylphorbol-13-acetate, Anti-inflammatory activity, Arachidonic acid, Croton oil, Epidermal growth factor, Mice, Psoriasis",

author = "\{Casac{\'o} Parada\}, A. and N. Led{\'o}n and A. Gonz{\'a}lez and N. Merino and R. P{\'e}rez",

year = "1999",

doi = "10.1159/000029848",

language = "English",

volume = "12",

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journal = "Skin Pharmacology and Applied Skin Physiology",

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T1 - Topical anti-inflammatory activity of human recombinant epidermal growth factor

AU - Casacó Parada, A.

AU - Ledón, N.

AU - González, A.

AU - Merino, N.

AU - Pérez, R.

PY - 1999

Y1 - 1999

N2 - The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-O-tetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 μg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.

AB - The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-O-tetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 μg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.

KW - 12-O-tetradecanoylphorbol-13-acetate

KW - Anti-inflammatory activity

KW - Arachidonic acid

KW - Croton oil

KW - Epidermal growth factor

KW - Mice

KW - Psoriasis

UR - https://www.scopus.com/pages/publications/0032995022

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DO - 10.1159/000029848

M3 - Article

C2 - 10325586

AN - SCOPUS:0032995022

SN - 1422-2868

VL - 12

SP - 79

EP - 84

JO - Skin Pharmacology and Applied Skin Physiology

JF - Skin Pharmacology and Applied Skin Physiology

IS - 1-2

ER -

Topical anti-inflammatory activity of human recombinant epidermal growth factor

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