Temperature control based on a modified smith predictor for injectable drug formulations

I. O. Benitez, R. Rivas, V. Feliu, F. J. Castillo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

17 Citas (Scopus)


This paper proposes a modified Smith predictor scheme for temperature control during the formulation of injectable drugs in chemical reactors. The dynamic model of this process is obtained from an identification procedure applied in a real chemical reactor of the pharmaceutical industry. This identification procedure yields a second order with dominant time delay transfer function. A PI controller combined with a modified Smith predictor is therefore designed which behaves robustly against the effect of measured or unmeasured external disturbances. Simulated results compare the performance of the proposed controller with a standard PI controller, also combined with a conventional Smith predictor, and with Astrom modified Smith predictor. Four performance indexes have been used in this comparison: three related to the output performance (settling time, overshooting, and IAE), and a fourth one related to the control effort (EU). The analysis of these indexes shows that the proposed controller provides lower values of the compared indexes.

Idioma originalInglés
Número de artículo7106355
Páginas (desde-hasta)1041-1047
Número de páginas7
PublicaciónIEEE Latin America Transactions
EstadoPublicada - 1 abr. 2015
Publicado de forma externa


Profundice en los temas de investigación de 'Temperature control based on a modified smith predictor for injectable drug formulations'. En conjunto forman una huella única.

Citar esto