Studies on the synthesis of di- and trisaccharide analogues of moenomycin A. Modifications in unit E and in the lipid part

Guangbin Yang; Madina Mansourova; Lothar Hennig; Matthias Findeisen; Ramona Oehme; Sabine Giesa; Peter Welzel

doi:10.1002/hlca.200490161

Studies on the synthesis of di- and trisaccharide analogues of moenomycin A. Modifications in unit E and in the lipid part

Guangbin Yang, Madina Mansourova, Lothar Hennig, Matthias Findeisen, Ramona Oehme, Sabine Giesa, Peter Welzel

University of Leipzig

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

11 Citas (Scopus)

Resumen

Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2-4). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin-type transglycosylase inhibitors in detail and for preparing analogues with improved pharmacokinetic properties.

Idioma original	Inglés
Páginas (desde-hasta)	1807-1824
Número de páginas	18
Publicación	Helvetica Chimica Acta
Volumen	87
N.º	7
DOI	https://doi.org/10.1002/hlca.200490161
Estado	Publicada - 2004
Publicado de forma externa	Sí

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abstract = "Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2-4). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin-type transglycosylase inhibitors in detail and for preparing analogues with improved pharmacokinetic properties.",

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AU - Findeisen, Matthias

AU - Oehme, Ramona

AU - Giesa, Sabine

AU - Welzel, Peter

PY - 2004

Y1 - 2004

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AB - Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2-4). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin-type transglycosylase inhibitors in detail and for preparing analogues with improved pharmacokinetic properties.

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Studies on the synthesis of di- and trisaccharide analogues of moenomycin A. Modifications in unit E and in the lipid part

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