Structure and estrogenic activity of new lignans from Iryanthera lancifolia

Dulce Mesa-Siverio, Rubén P. Machín, Ana Estévez-Braun, Ángel G. Ravelo, Olga Lock De Ugaz

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

13 Citas (Scopus)


Five new dibenzylbutane type lignans (1-5) were isolated from the stem bark of Iryanthera lancifolia. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies and chemical evidence. Seventeen of the isolated compounds were tested for their estrogenic activities in the estrogen responsive human breast cancer cell line MCF-7 BUS using the E-Screen proliferation assay. Cell proliferation was evaluated by the SRB assay to calculate the estrogenic parameters. The majority of the compounds induced a mitogenic response. This effect, given as Relative Proliferative Effect (RPE) to reference estrogen 17β-estradiol (E2), ranged between 14% and 84%. © 2007 Elsevier Ltd. All rights reserved.
Idioma originalEspañol
Páginas (desde-hasta)3387-3394
Número de páginas8
PublicaciónBioorganic and Medicinal Chemistry
EstadoPublicada - 15 mar. 2008
Publicado de forma externa

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