Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process

Robert Ccorahua, Silvia Moreno, Hannes Gumz, Karin Sahre, Brigitte Voit, Dietmar Appelhans

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

11 Citas (Scopus)

Resumen

Reconstitution of biologically active polymersomes from the frozen or solid state into any fluid state is still a challenging issue for the design of new biological experiments and for the formulation of therapeutic agents. To gain knowledge about the reconstitution of pH-responsive and photo-crosslinked polymersomes, surface-functionalized and enzyme-containing polymersomers were cryogenically frozen (-20 °C) or freeze-dried with inulin as the lyoprotectant (0.1% w/v) and stored for a defined time period. Reconstituting those polymersomes in solution by thawing or a re-dispersing process revealed their original physical properties as well as their function as a pH-switchable enzymatic nanoreactor.
Idioma originalEspañol
Páginas (desde-hasta)25436-25443
Número de páginas8
PublicaciónRSC Advances
Volumen8
EstadoPublicada - 1 ene. 2018
Publicado de forma externa

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