Priming and boosting determinants on the antibody response to an Epidermal Growth Factor-based cancer vaccine

Pedro C. Rodriguez; Ileana Gonzalez; Adys Gonzalez; Janet Avellanet; Armando Lopez; Rolando Perez; Agustin Lage; Enrique Montero

doi:10.1016/j.vaccine.2008.07.003

Priming and boosting determinants on the antibody response to an Epidermal Growth Factor-based cancer vaccine

Pedro C. Rodriguez, Ileana Gonzalez, Adys Gonzalez, Janet Avellanet, Armando Lopez, Rolando Perez, Agustin Lage, Enrique Montero

National School of Public Health

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

18 Citas (Scopus)

Resumen

Epidermal Growth Factor chemically conjugated to P64k carrier protein from Neisseria meningitidis emulsified in Montanide ISA 51 adjuvant is a cancer vaccine under clinical evaluation. We explored the influence of priming and boosting variables on the antibody response in mice. An apparently low dose fractionated in multiple anatomical sites at priming accelerated the induction and enhanced the maximal antibody response, with a long-lasting effect. Moreover, shortening the boosting time reduces the antibody persistence. Repeatedly boosting shift subjects to good antibody-responders, maintaining the epitope immunodominance. We conclude that optimizing immunopharmacological determinants contribute to an earlier, stronger and prolonged anti-EGF antibody persistence.

Idioma original	Inglés
Páginas (desde-hasta)	4647-4654
Número de páginas	8
Publicación	Vaccine
Volumen	26
N.º	36
DOI	https://doi.org/10.1016/j.vaccine.2008.07.003
Estado	Publicada - 26 ago. 2008
Publicado de forma externa	Sí

ODS de las Naciones Unidas

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title = "Priming and boosting determinants on the antibody response to an Epidermal Growth Factor-based cancer vaccine",

abstract = "Epidermal Growth Factor chemically conjugated to P64k carrier protein from Neisseria meningitidis emulsified in Montanide ISA 51 adjuvant is a cancer vaccine under clinical evaluation. We explored the influence of priming and boosting variables on the antibody response in mice. An apparently low dose fractionated in multiple anatomical sites at priming accelerated the induction and enhanced the maximal antibody response, with a long-lasting effect. Moreover, shortening the boosting time reduces the antibody persistence. Repeatedly boosting shift subjects to good antibody-responders, maintaining the epitope immunodominance. We conclude that optimizing immunopharmacological determinants contribute to an earlier, stronger and prolonged anti-EGF antibody persistence.",

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AU - Gonzalez, Adys

AU - Avellanet, Janet

AU - Lopez, Armando

AU - Perez, Rolando

AU - Lage, Agustin

AU - Montero, Enrique

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AB - Epidermal Growth Factor chemically conjugated to P64k carrier protein from Neisseria meningitidis emulsified in Montanide ISA 51 adjuvant is a cancer vaccine under clinical evaluation. We explored the influence of priming and boosting variables on the antibody response in mice. An apparently low dose fractionated in multiple anatomical sites at priming accelerated the induction and enhanced the maximal antibody response, with a long-lasting effect. Moreover, shortening the boosting time reduces the antibody persistence. Repeatedly boosting shift subjects to good antibody-responders, maintaining the epitope immunodominance. We conclude that optimizing immunopharmacological determinants contribute to an earlier, stronger and prolonged anti-EGF antibody persistence.

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Priming and boosting determinants on the antibody response to an Epidermal Growth Factor-based cancer vaccine

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