Neurosphere fate prediction: An analysis-synthesis approach for feature extraction

Stéphane U. Rigaud, Nicolas Loménie, Shvetha Sankaran, Sohail Ahmed, Joo Hwee Lim, Daniel Racoceanu

Producción científica: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

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Resumen

The study of stem cells is one of the current most important biomedical research field. Understanding their development could allow multiple applications in regenerative medicine. For this purpose, we need automated methods for the segmentation and the modeling of neural stem cell development process into a neurosphere colony from phase contrast microscopy. We use such methods to extract relevant structural and textural features like cell division dynamism and cell behavior patterns for biological interpretation. The combination of phase contrast imaging, high fragility and complex evolution of neural stem cells pose many challenges in image processing and image analysis. This study introduces an on-line analysis method for the modeling of neurosphere evolution during the first three days of their development. From the corresponding time-lapse sequences, we extract information from the neurosphere using a combination of fast level set and curve detection for segmenting the cells. Then, based on prior biological knowledge, we generate possible and optimal 3-dimensional configuration using registration and evolutionary optimisation algorithm.

Idioma originalInglés
Título de la publicación alojada2012 International Joint Conference on Neural Networks, IJCNN 2012
DOI
EstadoPublicada - 2012
Publicado de forma externa
Evento2012 Annual International Joint Conference on Neural Networks, IJCNN 2012, Part of the 2012 IEEE World Congress on Computational Intelligence, WCCI 2012 - Brisbane, QLD, Australia
Duración: 10 jun. 201215 jun. 2012

Serie de la publicación

NombreProceedings of the International Joint Conference on Neural Networks

Conferencia

Conferencia2012 Annual International Joint Conference on Neural Networks, IJCNN 2012, Part of the 2012 IEEE World Congress on Computational Intelligence, WCCI 2012
País/TerritorioAustralia
CiudadBrisbane, QLD
Período10/06/1215/06/12

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