Monitoring cell substrate interactions in exopolysaccharide-based films reinforced with chitin whiskers and starch nanoparticles used as cell substrates

Sol Rodríguez, Francesca Gatto, Luca Pesce, Claudio Canale, Pier Paolo Pompa, Giuseppe Bardi, Daniel Lopez, Fernando G. Torres

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

10 Citas (Scopus)

Resumen

Exopolysaccharides (EPS) extracted from Nostoc commune cyanobacteria were used to prepare low-adhesion cell substrates for tumor-selective cell growth. The substrates were reinforced with chitin whiskers and starch nanoparticles and characterized using Fourier transform infrared spectroscopy, X-ray diffraction, and tensile tests. Two anchorage independent cells, green fluorescent protein-modified HeLa and THP-1 cells were seeded on the samples to assess their interaction with the composites. The results confirmed the cell–surface interaction of EPS-based composites. The mechanical properties of these films can be tailored by controlling the type and concentration of the reinforcement, which can be used in the design of different types of biomaterials.

Idioma originalInglés
Páginas (desde-hasta)333-339
Número de páginas7
PublicaciónInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volumen67
N.º6
DOI
EstadoPublicada - 13 abr. 2018

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