Molecular detection of carbapenemases in critical microorganisms since the onset of the COVID-19 pandemic in Peru

Working group in the national surveillance of antimicrobial resistance

doi:10.1093/jacamr/dlaf203

Molecular detection of carbapenemases in critical microorganisms since the onset of the COVID-19 pandemic in Peru

Working group in the national surveillance of antimicrobial resistance

Instituto Nacional de Salud, Lima
Universidad Nacional Mayor de San Marcos
Universidad San Ignacio de Loyola
Hospital de Emergencias Ate Vitarte
Hospital de Emergencias Villa El Salvador
Hospital Central de la Fuerza Aérea del Perú
Hospital Nacional Arzobispo Loayza
Hospital Nacional Cayetano Heredia
Hospital de Emergencias J. Casimiro Ulloa
Hospital Nacional Edgardo Rebagliati M.
Hospital II Essalud Emergencias Grau
Hospital de Emergencias Pediátricas
Hospital Nacional Guillermo Almenara I.
Hospital Nacional Hipolito Unanue
Hospital José Agurto Tello de Chosica
Hospital de Apoyo María Auxiliadora
Hospital Militar Luis Arias Schereiber
Hospital Nacional Dos de Mayo
Hospital Nacional Docente Madre Niño San Bartolomé
Instituto Nacional de Cs. Neurológicas
Instituto Nacional Materno Perinatal, Lima
Instituto Nacional de Salud del Niño
Hospital Carlos Lanfranco La Hoz
Hospital Nacional Sergio E. Bernales
Hospital San Juan de Lurigancho
Clínica Centenario Peruano Japonesa
Clínica Delgado-Auna
Clínicas San Gabriel and San Pablo
Hospital Alberto L. Barton Thompson-Callao
EsSalud
Hospital Naval
Alberto Sabogal Sologuren National Hospital
Hospital Nacional Daniel A. Carrión
Hospital San José
Hospital Belén de Trujillo
Hospital R. Docente -Trujillo
Hospital de Alta Complejidad Essalud Virgen de la Puerta- la Libertad
Hospital Nacional III Carlos Alberto Seguin Escobedo
Ministerio de Salud del Perú
Instituto Regional de Enfermedades Neoplásicas-Sur
Hospital de Apoyo-Puquio 'Felipe Huamán P. de Ayalä
Hospital II Essalud Huamanga
Hospital Regional Miguel Ángel Mariscal Llerena
Hospital Regional Lambayeque
Hospital Hipólito Unanue de Tacna
Hospital II Essalud Abancay
Hospital Regional Guillermo Díaz de la Vega-Apurímac
Hospital Regional de Ica
Hospital II Essalud Huánuco
Hospital Herminio Balizan-Huánuco
Seguro Social de Salud del Perú
Hospital Eleazar Guzmán Barrón
Hospital 'Víctor Ramos Guardia"- Huaraz
Hospital R. Loreto 'Felipe S. Arriola Iglesias'
Hospital Regional Virgen de Fátima-Amazonas
Hospital Regional de Moquegua
Hospital Santa Rosa
Hospital Regional Docente Clínico Quirúrgico Daniel A. Carrión
Hospital Regional Docente Materno Infantil 'El Carmen'
Hospital II Pucallpa-Essalud

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

Objective Identify and characterize carbapenemase genes in bacterial isolates of Enterobacterales, Acinetobacter baumannii, and Pseudomonas aeruginosa collected through the National Surveillance of Antimicrobial Resistance (AMR) Program during the COVID-19 pandemic in Peru. Methods This retrospective, observational study analysed 2049 submitted due to suspected portability of carbapenemase genes, collected between January 2020 and August 2022. Samples were obtained from 61 hospitals in 18 of the 25 regions of Peru (72%) that participated in the National Surveillance AMR Program. Results Among the isolates, 860 were Enterobacterales, 771 were A. baumannii, and 418 were P. aeruginosa. Carbapenemase genes were detected in 1735 isolates (84,6%). The most prevalent genes identified were bla_NDM (561, 78.13%) in Enterobacterales, bla_OXA-24-like (488, 67.8%) in A. baumannii, and bla_IMP (188, 63.3%) in P. aeruginosa. Notably, rare occurrences of bla_NDM were identified in P. aeruginosa (5, 1.7%). Combinations of carbapenemase genes were identified including bla_IMP₊ bla_VIM in P. aeruginosa, with a rising trend, but also bla_KPC + bla_NDM (7, 1%) bla_NDM + bla_OXA-48-like (1, 0.14%), bla_NDM + bla_IMP (2, 0.3%), and bla_NDM + bla_VIM (2, 0.3%) in Enterobacterales; and bla_OXA-23 + bla_OXA-24-like (11, 1.5%), bla_NDM + bla_OXA-24-like (2, 0.3%), and bla_NDM + bla_OXA-58-like (1, 0.1%) in A. baumannii. Conclusion This study highlights the significant detection of carbapenemase genes and their combinations in Peru during the COVID-19 pandemic. These findings underscore the urgent need for enhanced AMR surveillance, antimicrobial stewardship, and targeted infection control strategies to address this critical public health threat.

Idioma original	Inglés
Número de artículo	dlaf203
Publicación	JAC-Antimicrobial Resistance
Volumen	7
N.º	6
DOI	https://doi.org/10.1093/jacamr/dlaf203
Estado	Publicada - 1 dic. 2025
Publicado de forma externa	Sí

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@article{567cc438ca1c44fd838caa8fc6b514a2,

title = "Molecular detection of carbapenemases in critical microorganisms since the onset of the COVID-19 pandemic in Peru",

abstract = "Objective Identify and characterize carbapenemase genes in bacterial isolates of Enterobacterales, Acinetobacter baumannii, and Pseudomonas aeruginosa collected through the National Surveillance of Antimicrobial Resistance (AMR) Program during the COVID-19 pandemic in Peru. Methods This retrospective, observational study analysed 2049 submitted due to suspected portability of carbapenemase genes, collected between January 2020 and August 2022. Samples were obtained from 61 hospitals in 18 of the 25 regions of Peru (72\%) that participated in the National Surveillance AMR Program. Results Among the isolates, 860 were Enterobacterales, 771 were A. baumannii, and 418 were P. aeruginosa. Carbapenemase genes were detected in 1735 isolates (84,6\%). The most prevalent genes identified were blaNDM (561, 78.13\%) in Enterobacterales, blaOXA-24-like (488, 67.8\%) in A. baumannii, and blaIMP (188, 63.3\%) in P. aeruginosa. Notably, rare occurrences of blaNDM were identified in P. aeruginosa (5, 1.7\%). Combinations of carbapenemase genes were identified including blaIMP+ blaVIM in P. aeruginosa, with a rising trend, but also blaKPC + blaNDM (7, 1\%) blaNDM + blaOXA-48-like (1, 0.14\%), blaNDM + blaIMP (2, 0.3\%), and blaNDM + blaVIM (2, 0.3\%) in Enterobacterales; and blaOXA-23 + blaOXA-24-like (11, 1.5\%), blaNDM + blaOXA-24-like (2, 0.3\%), and blaNDM + blaOXA-58-like (1, 0.1\%) in A. baumannii. Conclusion This study highlights the significant detection of carbapenemase genes and their combinations in Peru during the COVID-19 pandemic. These findings underscore the urgent need for enhanced AMR surveillance, antimicrobial stewardship, and targeted infection control strategies to address this critical public health threat.",

author = "\{Working group in the national surveillance of antimicrobial resistance\} and Maritza Mayta-Barrios and Juan Ram{\'i}rez-Illescas and Juan Pacori and Joshi Acosta and Luis Pampa-Espinoza and Javier Silva-Valencia and Alicia N{\'u}{\~n}ez-Llanos and Celinda Bendez{\'u} and Kevin Serrano and Mart{\'i}n Yagui-Moscoso and T. Dijango and G. Rosas and H. Ch{\'a}vez and M. Cano and A. Urbano and R. Hern{\'a}ndez and A. Salazar and K. Amaro and E. Salazar and J. Figueroa and J. Diaz and M. Cruzado and F. Pr{\'i}ncipe and B. Paredes and C. Pa{\'u}car and R. Sandoval and M. Ch{\'a}vez and E. Sierra and C. Rojas and C. Valera and D. Bohorquez and G. Salvador and C. Cucho and J. Soto and R. Pissani and T. Huaytaya and G. Sosa and T. Vela and C. Quispe and P. Virna and K. Paredes and A. Olivares and P. Berrios and E. Tapia and J. Lagos and A. Castro and J. Alva and D. Palacin and F. C{\'a}rdenas and N. Campos",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.",

year = "2025",

month = dec,

day = "1",

doi = "10.1093/jacamr/dlaf203",

language = "English",

volume = "7",

journal = "JAC-Antimicrobial Resistance",

issn = "2632-1823",

number = "6",

}

TY - JOUR

T1 - Molecular detection of carbapenemases in critical microorganisms since the onset of the COVID-19 pandemic in Peru

AU - Working group in the national surveillance of antimicrobial resistance

AU - Mayta-Barrios, Maritza

AU - Ramírez-Illescas, Juan

AU - Pacori, Juan

AU - Acosta, Joshi

AU - Pampa-Espinoza, Luis

AU - Silva-Valencia, Javier

AU - Núñez-Llanos, Alicia

AU - Bendezú, Celinda

AU - Serrano, Kevin

AU - Yagui-Moscoso, Martín

AU - Dijango, T.

AU - Rosas, G.

AU - Chávez, H.

AU - Cano, M.

AU - Urbano, A.

AU - Hernández, R.

AU - Salazar, A.

AU - Amaro, K.

AU - Salazar, E.

AU - Figueroa, J.

AU - Diaz, J.

AU - Cruzado, M.

AU - Príncipe, F.

AU - Paredes, B.

AU - Paúcar, C.

AU - Sandoval, R.

AU - Chávez, M.

AU - Sierra, E.

AU - Rojas, C.

AU - Valera, C.

AU - Bohorquez, D.

AU - Salvador, G.

AU - Cucho, C.

AU - Soto, J.

AU - Pissani, R.

AU - Huaytaya, T.

AU - Sosa, G.

AU - Vela, T.

AU - Quispe, C.

AU - Virna, P.

AU - Paredes, K.

AU - Olivares, A.

AU - Berrios, P.

AU - Tapia, E.

AU - Lagos, J.

AU - Castro, A.

AU - Alva, J.

AU - Palacin, D.

AU - Cárdenas, F.

AU - Campos, N.

PY - 2025/12/1

Y1 - 2025/12/1

N2 - Objective Identify and characterize carbapenemase genes in bacterial isolates of Enterobacterales, Acinetobacter baumannii, and Pseudomonas aeruginosa collected through the National Surveillance of Antimicrobial Resistance (AMR) Program during the COVID-19 pandemic in Peru. Methods This retrospective, observational study analysed 2049 submitted due to suspected portability of carbapenemase genes, collected between January 2020 and August 2022. Samples were obtained from 61 hospitals in 18 of the 25 regions of Peru (72%) that participated in the National Surveillance AMR Program. Results Among the isolates, 860 were Enterobacterales, 771 were A. baumannii, and 418 were P. aeruginosa. Carbapenemase genes were detected in 1735 isolates (84,6%). The most prevalent genes identified were blaNDM (561, 78.13%) in Enterobacterales, blaOXA-24-like (488, 67.8%) in A. baumannii, and blaIMP (188, 63.3%) in P. aeruginosa. Notably, rare occurrences of blaNDM were identified in P. aeruginosa (5, 1.7%). Combinations of carbapenemase genes were identified including blaIMP+ blaVIM in P. aeruginosa, with a rising trend, but also blaKPC + blaNDM (7, 1%) blaNDM + blaOXA-48-like (1, 0.14%), blaNDM + blaIMP (2, 0.3%), and blaNDM + blaVIM (2, 0.3%) in Enterobacterales; and blaOXA-23 + blaOXA-24-like (11, 1.5%), blaNDM + blaOXA-24-like (2, 0.3%), and blaNDM + blaOXA-58-like (1, 0.1%) in A. baumannii. Conclusion This study highlights the significant detection of carbapenemase genes and their combinations in Peru during the COVID-19 pandemic. These findings underscore the urgent need for enhanced AMR surveillance, antimicrobial stewardship, and targeted infection control strategies to address this critical public health threat.

AB - Objective Identify and characterize carbapenemase genes in bacterial isolates of Enterobacterales, Acinetobacter baumannii, and Pseudomonas aeruginosa collected through the National Surveillance of Antimicrobial Resistance (AMR) Program during the COVID-19 pandemic in Peru. Methods This retrospective, observational study analysed 2049 submitted due to suspected portability of carbapenemase genes, collected between January 2020 and August 2022. Samples were obtained from 61 hospitals in 18 of the 25 regions of Peru (72%) that participated in the National Surveillance AMR Program. Results Among the isolates, 860 were Enterobacterales, 771 were A. baumannii, and 418 were P. aeruginosa. Carbapenemase genes were detected in 1735 isolates (84,6%). The most prevalent genes identified were blaNDM (561, 78.13%) in Enterobacterales, blaOXA-24-like (488, 67.8%) in A. baumannii, and blaIMP (188, 63.3%) in P. aeruginosa. Notably, rare occurrences of blaNDM were identified in P. aeruginosa (5, 1.7%). Combinations of carbapenemase genes were identified including blaIMP+ blaVIM in P. aeruginosa, with a rising trend, but also blaKPC + blaNDM (7, 1%) blaNDM + blaOXA-48-like (1, 0.14%), blaNDM + blaIMP (2, 0.3%), and blaNDM + blaVIM (2, 0.3%) in Enterobacterales; and blaOXA-23 + blaOXA-24-like (11, 1.5%), blaNDM + blaOXA-24-like (2, 0.3%), and blaNDM + blaOXA-58-like (1, 0.1%) in A. baumannii. Conclusion This study highlights the significant detection of carbapenemase genes and their combinations in Peru during the COVID-19 pandemic. These findings underscore the urgent need for enhanced AMR surveillance, antimicrobial stewardship, and targeted infection control strategies to address this critical public health threat.

UR - https://www.scopus.com/pages/publications/105021475356

U2 - 10.1093/jacamr/dlaf203

DO - 10.1093/jacamr/dlaf203

M3 - Article

AN - SCOPUS:105021475356

SN - 2632-1823

VL - 7

JO - JAC-Antimicrobial Resistance

JF - JAC-Antimicrobial Resistance

IS - 6

M1 - dlaf203

ER -

Molecular detection of carbapenemases in critical microorganisms since the onset of the COVID-19 pandemic in Peru

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