Intracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles

Laura Comas; Esther Polo; M. Pilar Domingo; Yulán Hernández; Maykel Arias; Patricia Esteban; Luis Martínez-Lostao; Julián Pardo; Jesús M. de la Fuente; Eva M. Gálvez

Intracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles

Laura Comas, Esther Polo, M. Pilar Domingo, Yulán Hernández, Maykel Arias, Patricia Esteban, Luis Martínez-Lostao, Julián Pardo, Jesús M. de la Fuente, Eva M. Gálvez

Sección de Química

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

8 Citas (Scopus)

Resumen

Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer.

Idioma original	Español
Publicación	Materials
Volumen	12
Estado	Publicada - 1 ene. 2019

Citar esto

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title = "Intracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles",

abstract = "Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer.",

author = "Laura Comas and Esther Polo and Domingo, {M. Pilar} and Yul{\'a}n Hern{\'a}ndez and Maykel Arias and Patricia Esteban and Luis Mart{\'i}nez-Lostao and Juli{\'a}n Pardo and {de la Fuente}, {Jes{\'u}s M.} and G{\'a}lvez, {Eva M.}",

year = "2019",

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language = "Espa{\~n}ol",

volume = "12",

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TY - JOUR

T1 - Intracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles

AU - Comas, Laura

AU - Polo, Esther

AU - Domingo, M. Pilar

AU - Hernández, Yulán

AU - Arias, Maykel

AU - Esteban, Patricia

AU - Martínez-Lostao, Luis

AU - Pardo, Julián

AU - de la Fuente, Jesús M.

AU - Gálvez, Eva M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer.

AB - Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer.

M3 - Artículo

SN - 1996-1944

VL - 12

JO - Materials

JF - Materials

ER -