Intracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles

Laura Comas; Esther Polo; M. Pilar Domingo; Yulán Hernández; Maykel Arias; Patricia Esteban; Luis Martínez-Lostao; Julián Pardo; Jesús Martínez de la Fuente; Eva M. Gálvez

doi:10.3390/ma12071092

Intracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles

Laura Comas, Esther Polo, M. Pilar Domingo, Yulán Hernández, Maykel Arias, Patricia Esteban, Luis Martínez-Lostao, Julián Pardo, Jesús Martínez de la Fuente, Eva M. Gálvez

Sección de Química

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

8 Citas (Scopus)

Resumen

Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer.

Idioma original	Inglés
Número de artículo	1092
Publicación	Materials
Volumen	12
N.º	7
DOI	https://doi.org/10.3390/ma12071092
Estado	Publicada - 2019

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title = "Intracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles",

abstract = "Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer.",

keywords = "Cancer cells, Drug delivery, Gliotoxin, Magnetic nanoparticles, Therapeutic",

author = "Laura Comas and Esther Polo and Domingo, {M. Pilar} and Yul{\'a}n Hern{\'a}ndez and Maykel Arias and Patricia Esteban and Luis Mart{\'i}nez-Lostao and Juli{\'a}n Pardo and {de la Fuente}, {Jes{\'u}s Mart{\'i}nez} and G{\'a}lvez, {Eva M.}",

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T1 - Intracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles

AU - Comas, Laura

AU - Polo, Esther

AU - Domingo, M. Pilar

AU - Hernández, Yulán

AU - Arias, Maykel

AU - Esteban, Patricia

AU - Martínez-Lostao, Luis

AU - Pardo, Julián

AU - de la Fuente, Jesús Martínez

AU - Gálvez, Eva M.

PY - 2019

Y1 - 2019

N2 - Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer.

AB - Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer.

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KW - Drug delivery

KW - Gliotoxin

KW - Magnetic nanoparticles

KW - Therapeutic

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Intracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles

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