Identification of transforming growth factor alpha in human primary breast carcinomas

A. Macias; R. Perez; T. Hagerstrom; L. Skoog

Identification of transforming growth factor alpha in human primary breast carcinomas

A. Macias, R. Perez, T. Hagerstrom, L. Skoog

Instituto Nacional de Oncologia y Radiobiologia, Havana, cu

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25 Citas (Scopus)

Resumen

Primary human mammary carcinomas were found to contain an acid stable polypeptide which bound to the receptor for epidermal growth factor (EGF). This polypeptide which was antigenetically different from EGF and thus identified as Tumor Growth Factor (TGF) alpha, could be identified in 25% or the tumors. Among these tumors 40% contained measurable levels of the EGF receptor. Thus these tumors exhibit the molecular prerequisite for autocrine growth stimulation.

Idioma original	Inglés
Páginas (desde-hasta)	1271-1276
Número de páginas	6
Publicación	Anticancer Research
Volumen	7
N.º	6
Estado	Publicada - 1987
Publicado de forma externa	Sí

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@article{1a4e4a82426f4063ae67beb9b185ae88,

title = "Identification of transforming growth factor alpha in human primary breast carcinomas",

abstract = "Primary human mammary carcinomas were found to contain an acid stable polypeptide which bound to the receptor for epidermal growth factor (EGF). This polypeptide which was antigenetically different from EGF and thus identified as Tumor Growth Factor (TGF) alpha, could be identified in 25% or the tumors. Among these tumors 40% contained measurable levels of the EGF receptor. Thus these tumors exhibit the molecular prerequisite for autocrine growth stimulation.",

author = "A. Macias and R. Perez and T. Hagerstrom and L. Skoog",

year = "1987",

language = "English",

volume = "7",

pages = "1271--1276",

journal = "Anticancer Research",

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TY - JOUR

T1 - Identification of transforming growth factor alpha in human primary breast carcinomas

AU - Macias, A.

AU - Perez, R.

AU - Hagerstrom, T.

AU - Skoog, L.

PY - 1987

Y1 - 1987

N2 - Primary human mammary carcinomas were found to contain an acid stable polypeptide which bound to the receptor for epidermal growth factor (EGF). This polypeptide which was antigenetically different from EGF and thus identified as Tumor Growth Factor (TGF) alpha, could be identified in 25% or the tumors. Among these tumors 40% contained measurable levels of the EGF receptor. Thus these tumors exhibit the molecular prerequisite for autocrine growth stimulation.

AB - Primary human mammary carcinomas were found to contain an acid stable polypeptide which bound to the receptor for epidermal growth factor (EGF). This polypeptide which was antigenetically different from EGF and thus identified as Tumor Growth Factor (TGF) alpha, could be identified in 25% or the tumors. Among these tumors 40% contained measurable levels of the EGF receptor. Thus these tumors exhibit the molecular prerequisite for autocrine growth stimulation.

UR - http://www.scopus.com/inward/record.url?scp=0023548364&partnerID=8YFLogxK

M3 - Article

C2 - 3502066

AN - SCOPUS:0023548364

SN - 0250-7005

VL - 7

SP - 1271

EP - 1276

JO - Anticancer Research

JF - Anticancer Research

IS - 6

ER -

Identification of transforming growth factor alpha in human primary breast carcinomas

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