Generation of a murine monoclonal antibody specific for N- glycolylneuraminic acid-containing gangliosides that also recognizes sulfated glycolipids

A. M. Vazquez, M. Alfonso, B. Lanne, K. A. Karlsson, A. Carr, O. Barroso, L. E. Fernandez, E. Rengifo, M. E. Lanio, C. Alvarez, J. Zeuthen, R. Perez

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80 Citas (Scopus)

Resumen

The P3 murine monoclonal antibody (MAb) was generated by immunizing BALB/c mice with NeuGcGM3 included into liposomes. The specificity of this MAb was defined by an enzyme-linked immunosorbent assay and immunostaining on thin- layer chromatograms. P3 MAb binds to NeuGc-containing gangliosides and was shown also to react with sulfated glycolipids. A preliminary immunohistochemical study showed that the P3 MAb was able to recognize antigens expressed in human breast tumors.

Idioma originalInglés
Páginas (desde-hasta)551-556
Número de páginas6
PublicaciónHybridoma
Volumen14
N.º6
DOI
EstadoPublicada - 1995
Publicado de forma externa

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Profundice en los temas de investigación de 'Generation of a murine monoclonal antibody specific for N- glycolylneuraminic acid-containing gangliosides that also recognizes sulfated glycolipids'. En conjunto forman una huella única.

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