Gangliosides expressed in human breast cancer

Gilda Marquina, Hatsue Waki, Luis E. Fernandez, Kazuo Kon, Adriana Carr, Oscar Valiente, Rolando Perez, Susumu Ando

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

236 Citas (Scopus)

Resumen

Breast tumors that were histopathologically diagnosed as invasive ductal carcinoma were examined in relation to their abnormal expression of gangliosides. Total ganglioside levels that were expressed as lipid-bound sialic acids were significantly higher in breast tumor tissues than in normal mammary tissues. Two kinds of unusual gangliosides were found to be expressed in many cases of breast tumors. One was a group of O-acetylated gangliosides, such as O-acetyl-GD3 and O-acetyl-GT3. They are known as fetal gangliosides, which appear in fetal brains. The other was an N-glycolylneuraminic acid- containing ganglioside, N-glycolyl-GM3, which had not been previously found in normal human tissues. The finding that unusual gangliosides are expressed in breast tumors may provide the basis for their immunological diagnosis and vaccine therapy.

Idioma originalInglés
Páginas (desde-hasta)5165-5171
Número de páginas7
PublicaciónCancer Research
Volumen56
N.º22
EstadoPublicada - 15 nov. 1996
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Gangliosides expressed in human breast cancer'. En conjunto forman una huella única.

Citar esto