Epidermal growth factor receptors in human breast cancer

Rolando Pérez; María Pascual; Amparo Macías; Agustín Lage

doi:10.1007/BF01806484

Epidermal growth factor receptors in human breast cancer

Rolando Pérez, María Pascual, Amparo Macías, Agustín Lage

Instituto Nacional de Oncologia y Radiobiologia, Havana, cu

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Resumen

The capacity for specific binding of¹²⁵I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.

Idioma original	Inglés
Páginas (desde-hasta)	189-193
Número de páginas	5
Publicación	Breast Cancer Research and Treatment
Volumen	4
N.º	3
DOI	https://doi.org/10.1007/BF01806484
Estado	Publicada - set. 1984
Publicado de forma externa	Sí

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title = "Epidermal growth factor receptors in human breast cancer",

abstract = "The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.",

keywords = "breast cancer, EGF receptor, estrogen receptor, growth factors",

author = "Rolando P{\'e}rez and Mar{\'i}a Pascual and Amparo Mac{\'i}as and Agust{\'i}n Lage",

year = "1984",

month = sep,

doi = "10.1007/BF01806484",

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AU - Pérez, Rolando

AU - Pascual, María

AU - Macías, Amparo

AU - Lage, Agustín

PY - 1984/9

Y1 - 1984/9

N2 - The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.

AB - The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.

KW - breast cancer

KW - EGF receptor

KW - estrogen receptor

KW - growth factors

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JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

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ER -

Epidermal growth factor receptors in human breast cancer

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