TY - GEN
T1 - Curcumin-Loaded Poloxamer 407 Nanoparticles for Wound Healing Applications
T2 - 10th Latin American Congress of Biomedical Engineering, CLAIB 2024
AU - Cespedes, Sofia
AU - Elgegren, Mariela
AU - Kim, Suyeon
AU - Nakamatsu, Javier
AU - Torres, Lizardo
AU - Castillo, Denis
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.
PY - 2025
Y1 - 2025
N2 - Curcumin offers a promising potential for wound healing applications due to its pharmacological properties, such as antibacterial, antioxidant, and anti-inflammatory activities. This article presents the synthesis of curcumin-loaded poloxamer nanoparticles (CurP-NPs) as a potential drug delivery system for wound healing to circumvent the limitations of curcumin’s clinical utility, such as water insolubility and poor bioavailability. Curcumin and poloxamer concentrations were optimized for CurP-NPs formulation by measuring particle size, polydispersity, and zeta potential. The morphology of CurP-NPs was studied with scanning electron microscopy (SEM). The comparative studies on the antioxidant activity of lyophilized curcumin powder and CurP-NPs were carried out by ABTS cationic radical decolorization assay. Furthermore, the qualitative study of antibacterial activity was carried out by bioautography analysis against the large positive bacteria Staphylococcus aureus. The results showed that the optimal concentration of CurP-NPs was 1.33 g/L, with the smallest size of 95.37 ± 9.2 nm and a PDI of 0.28. In addition, greater antioxidant activity was observed (54%) compared to other concentrations evaluated. Ultimately, CurP-NPs showed an inhibition zone of 1.08 mm, indicating significant antimicrobial potential.
AB - Curcumin offers a promising potential for wound healing applications due to its pharmacological properties, such as antibacterial, antioxidant, and anti-inflammatory activities. This article presents the synthesis of curcumin-loaded poloxamer nanoparticles (CurP-NPs) as a potential drug delivery system for wound healing to circumvent the limitations of curcumin’s clinical utility, such as water insolubility and poor bioavailability. Curcumin and poloxamer concentrations were optimized for CurP-NPs formulation by measuring particle size, polydispersity, and zeta potential. The morphology of CurP-NPs was studied with scanning electron microscopy (SEM). The comparative studies on the antioxidant activity of lyophilized curcumin powder and CurP-NPs were carried out by ABTS cationic radical decolorization assay. Furthermore, the qualitative study of antibacterial activity was carried out by bioautography analysis against the large positive bacteria Staphylococcus aureus. The results showed that the optimal concentration of CurP-NPs was 1.33 g/L, with the smallest size of 95.37 ± 9.2 nm and a PDI of 0.28. In addition, greater antioxidant activity was observed (54%) compared to other concentrations evaluated. Ultimately, CurP-NPs showed an inhibition zone of 1.08 mm, indicating significant antimicrobial potential.
KW - Antimicrobial Activity
KW - Antioxidant
KW - Curcumin
KW - Nanoparticles
KW - Wound Healing
UR - https://www.scopus.com/pages/publications/105006418016
U2 - 10.1007/978-3-031-89510-4_19
DO - 10.1007/978-3-031-89510-4_19
M3 - Conference contribution
AN - SCOPUS:105006418016
SN - 9783031895098
T3 - IFMBE Proceedings
SP - 215
EP - 226
BT - 10th Latin American Congress on Biomedical Engineering - Proceedings of CLAIB 2024
A2 - Martinez-Licona, Fabiola M.
A2 - Ballarin, Virginia L.
A2 - Ibarra-Ramírez, Ernesto A.
A2 - Perez-Buitrago, Sandra M.
A2 - Berriere, Luis R.
PB - Springer Science and Business Media Deutschland GmbH
Y2 - 2 October 2024 through 5 October 2024
ER -