Constituents of Werneria ciliolata and their in vitro anti-hiv activity

Sonia Piacente; Rita Aquino; Nunziatina De Tommasi; Cosimo Pizza; Olga Lock de Ugaz; Day'dee Chavez Orellana; Naheed Mahmood

Constituents of Werneria ciliolata and their in vitro anti-hiv activity

Sonia Piacente, Rita Aquino, Nunziatina De Tommasi, Cosimo Pizza, Olga Lock de Ugaz, Day'dee Chavez Orellana, Naheed Mahmood

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Resumen

The aerial part of Werneria ciliolata afforded a series of new diterpenes: two ent-kaurane derivatives, a nor-kaurane, an ent-manoyloxide derivative, a dimeric diterpene, as well as a rare diterpene. Their structures were elucidated by spectroscopic methods, including the concerted application of 1D NMR techniques (DEPT and NOEDS) and 2D NMR techniques (1H-1H COSY and HETCOR). In addition, four known kauranes, four coumarins and 6-hydroxytremetone were isolated. All isolated compounds from W. ciliolata and W. dactylophylla were tested in vitro for anti-viral activity against HIV-1, but only 6-hydroxytremetone showed a significant anti-HIV-1 activity. © 1994.

Idioma original	Español
Páginas (desde-hasta)	991-996
Número de páginas	6
Publicación	Phytochemistry
Volumen	36
Estado	Publicada - 1 ene. 1994
Publicado de forma externa	Sí

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title = "Constituents of Werneria ciliolata and their in vitro anti-hiv activity",

abstract = "The aerial part of Werneria ciliolata afforded a series of new diterpenes: two ent-kaurane derivatives, a nor-kaurane, an ent-manoyloxide derivative, a dimeric diterpene, as well as a rare diterpene. Their structures were elucidated by spectroscopic methods, including the concerted application of 1D NMR techniques (DEPT and NOEDS) and 2D NMR techniques (1H-1H COSY and HETCOR). In addition, four known kauranes, four coumarins and 6-hydroxytremetone were isolated. All isolated compounds from W. ciliolata and W. dactylophylla were tested in vitro for anti-viral activity against HIV-1, but only 6-hydroxytremetone showed a significant anti-HIV-1 activity. {\textcopyright} 1994.",

author = "Sonia Piacente and Rita Aquino and {De Tommasi}, Nunziatina and Cosimo Pizza and {Lock de Ugaz}, Olga and {Chavez Orellana}, Day'dee and Naheed Mahmood",

year = "1994",

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language = "Espa{\~n}ol",

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TY - JOUR

T1 - Constituents of Werneria ciliolata and their in vitro anti-hiv activity

AU - Piacente, Sonia

AU - Aquino, Rita

AU - De Tommasi, Nunziatina

AU - Pizza, Cosimo

AU - Lock de Ugaz, Olga

AU - Chavez Orellana, Day'dee

AU - Mahmood, Naheed

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The aerial part of Werneria ciliolata afforded a series of new diterpenes: two ent-kaurane derivatives, a nor-kaurane, an ent-manoyloxide derivative, a dimeric diterpene, as well as a rare diterpene. Their structures were elucidated by spectroscopic methods, including the concerted application of 1D NMR techniques (DEPT and NOEDS) and 2D NMR techniques (1H-1H COSY and HETCOR). In addition, four known kauranes, four coumarins and 6-hydroxytremetone were isolated. All isolated compounds from W. ciliolata and W. dactylophylla were tested in vitro for anti-viral activity against HIV-1, but only 6-hydroxytremetone showed a significant anti-HIV-1 activity. © 1994.

AB - The aerial part of Werneria ciliolata afforded a series of new diterpenes: two ent-kaurane derivatives, a nor-kaurane, an ent-manoyloxide derivative, a dimeric diterpene, as well as a rare diterpene. Their structures were elucidated by spectroscopic methods, including the concerted application of 1D NMR techniques (DEPT and NOEDS) and 2D NMR techniques (1H-1H COSY and HETCOR). In addition, four known kauranes, four coumarins and 6-hydroxytremetone were isolated. All isolated compounds from W. ciliolata and W. dactylophylla were tested in vitro for anti-viral activity against HIV-1, but only 6-hydroxytremetone showed a significant anti-HIV-1 activity. © 1994.

M3 - Artículo

SN - 0031-9422

VL - 36

SP - 991

EP - 996

JO - Phytochemistry

JF - Phytochemistry

ER -