TY - JOUR
T1 - CoDNaS-RNA
T2 - A database of conformational diversity in the native state of RNA
AU - González Buitrón, Martín
AU - Tunque Cahui, Ronaldo Romario
AU - Garciá Ríos, Emilio
AU - Hirsh, Layla
AU - Parisi, Gustavo
AU - Fornasari, Mariá Silvina
AU - Palopoli, Nicolas
N1 - Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press. All rights reserved.
PY - 2022/3/15
Y1 - 2022/3/15
N2 - Summary: Conformational changes in RNA native ensembles are central to fulfill many of their biological roles. Systematic knowledge of the extent and possible modulators of this conformational diversity is desirable to better understand the relationship between RNA dynamics and function. We have developed CoDNaS-RNA as the first database of conformational diversity in RNA molecules. Known RNA structures are retrieved and clustered to identify alternative conformers of each molecule. Pairwise structural comparisons between all conformers within each cluster allows to measure the variability of the molecule. Additional annotations about structural features, molecular interactions and biological function are provided. All data in CoDNaS-RNA is free to download and available as a public website that can be of interest for researchers in computational biology and other life science disciplines.
AB - Summary: Conformational changes in RNA native ensembles are central to fulfill many of their biological roles. Systematic knowledge of the extent and possible modulators of this conformational diversity is desirable to better understand the relationship between RNA dynamics and function. We have developed CoDNaS-RNA as the first database of conformational diversity in RNA molecules. Known RNA structures are retrieved and clustered to identify alternative conformers of each molecule. Pairwise structural comparisons between all conformers within each cluster allows to measure the variability of the molecule. Additional annotations about structural features, molecular interactions and biological function are provided. All data in CoDNaS-RNA is free to download and available as a public website that can be of interest for researchers in computational biology and other life science disciplines.
UR - http://www.scopus.com/inward/record.url?scp=85126636308&partnerID=8YFLogxK
U2 - 10.1093/bioinformatics/btab858
DO - 10.1093/bioinformatics/btab858
M3 - Article
C2 - 34954795
AN - SCOPUS:85126636308
SN - 1367-4803
VL - 38
SP - 1745
EP - 1748
JO - Bioinformatics
JF - Bioinformatics
IS - 6
ER -