Characterization of the colorectal antigen IOR-C2

A. M. Vazquez, B. Tormo, A. Velandia, R. Giscombe, I. Ansotegui, M. Jeddi-Tehrani, R. Perez, H. Mellstedt, P. Biberfeld

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

13 Citas (Scopus)


A colorectal antigen (IOR-C2) was characterized by a monoclonal antibody produced against the colon cancer cell line SW1116. By immunohistochemical staining the antigen was abundant and strongly expressed in epithelium of normal colon whereas colorectal carcinomas showed a more variable and heterogenous reactivity to the antibody (IOR-C2). Radioimmunoprecipitates of SW1116 cell homogenates showed a 160-200 kD band in SDS gels. Physicochemical characterization indicate that at least two IOR-C2 reactive sites are present on the antigen tested and that it is mainly an 0-linked glycoprotein carbohydrate chain which can also be N-linked to the protein. The expression of IOR-C2 mimics that of the colon associated antigen (CAA) and NCC-CO-450 antigen but is distinct from these with regard to its expression in carcinomas as well as its physicochemical characteristics.

Idioma originalInglés
Páginas (desde-hasta)245-256
Número de páginas12
EstadoPublicada - 1992
Publicado de forma externa


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