Analysis of the spatial distribution of prostate cancer obtained from histopathological images

Kristians Diaz, Benjamin Castaneda, Maria Luisa Montero, Jorge Yao, Jean Joseph, Deborah Rubens, Kevin J. Parker

Producción científica: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

3 Citas (Scopus)


Understanding the spatial distribution of prostate cancer and how it changes according to prostate specific antigen (PSA) values, Gleason score, and other clinical parameters may help comprehend the disease and increase the overall success rate of biopsies. This work aims to build 3D spatial distributions of prostate cancer and examine the extent and location of cancer as a function of independent clinical parameters. The border of the gland and cancerous regions from whole-mount histopathological images are used to reconstruct 3D models showing the localization of tumor. This process utilizes color segmentation and interpolation based on mathematical morphological distance. 58 glands are deformed into one prostate atlas using a combination of rigid, affine, and b-spline deformable registration techniques. Spatial distribution is developed by counting the number of occurrences in a given position in 3D space from each registered prostate cancer. Finally a difference between proportions is used to compare different spatial distributions. Results show that prostate cancer has a significant difference (SD) in the right zone of the prostate between populations with PSA greater and less than 5ng/ml. Age does not have any impact in the spatial distribution of the disease. Positive and negative capsule-penetrated cases show a SD in the right posterior zone. There is SD in almost all the glands between cases with tumors larger and smaller than 10% of the whole prostate. A larger database is needed to improve the statistical validity of the test. Finally, information from whole-mount histopathological images may provide better insight into prostate cancer.

Idioma originalInglés
Título de la publicación alojadaMedical Imaging 2013
Subtítulo de la publicación alojadaDigital Pathology
EstadoPublicada - 2013
EventoSPIE Medical Imaging Symposium 2013: Digital Pathology - Lake Buena Vista, FL, Estados Unidos
Duración: 10 feb. 201311 feb. 2013

Serie de la publicación

NombreProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (versión impresa)1605-7422


ConferenciaSPIE Medical Imaging Symposium 2013: Digital Pathology
País/TerritorioEstados Unidos
CiudadLake Buena Vista, FL


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