A glucosinolate metabolism pathway in living plant cells mediates broad-spectrum antifungal defense

Paweł Bednarek, Mariola Piślewska-Bednarek, Aleš Svatoš, Bernd Schneider, Jan Doubský, Madina Mansurova, Matt Humphry, Chiara Consonni, Ralph Panstruga, Andrea Sanchez-Vallet, Antonio Molina, Paul Schulze-Lefert

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

767 Citas (Scopus)

Resumen

Selection pressure exerted by insects and microorganisms shapes the diversity of plant secondary metabolites. We identified a metabolic pathway for glucosinolates, known insect deterrents, that differs from the pathway activated by chewing insects. This pathway is active in living plant cells, may contribute to glucosinolate turnover, and has been recruited for broad-spectrum antifungal defense responses. The Arabidopsis CYP81F2 gene encodes a P450 monooxygenase that is essential for the pathogen-induced accumulation of 4-methoxyindol-3-ylmethylglucosinolate, which in turn is activated by the atypical PEN2 myrosinase (a type of β-thioglucoside glucohydrolase) for antifungal defense. We propose that reiterated enzymatic cycles, controlling the generation of toxic molecules and their detoxification, enable the recruitment of glucosinolates in defense responses.

Idioma originalInglés
Páginas (desde-hasta)101-106
Número de páginas6
PublicaciónScience
Volumen323
N.º5910
DOI
EstadoPublicada - 2 ene. 2009
Publicado de forma externa

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