Toward automatic phenotyping of retinal images from genetically determined mono-and dizygotic twins using amplitude modulation-frequency modulation methods

P. Soliz, B. Davis, V. Murray, M. Pattichis, S. Barriga, S. Russell

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

This paper presents an image processing technique for automatically categorize age-related macular degeneration (AMD) phenotypes from retinal images. Ultimately, an automated approach will be much more precise and consistent in phenotyping of retinal diseases, such as AMD. We have applied the automated phenotyping to retina images from a cohort of mono-and dizygotic twins. The application of this technology will allow one to perform more quantitative studies that will lead to a better understanding of the genetic and environmental factors associated with diseases such as AMD. A method for classifying retinal images based on features derived from the application of amplitude-modulation frequency-modulation (AM-FM) methods is presented. Retinal images from identical and fraternal twins who presented with AMD were processed to determine whether AM-FM could be used to differentiate between the two types of twins. Results of the automatic classifier agreed with the findings of other researchers in explaining the variation of the disease between the related twins. AM-FM features classified 72% of the twins correctly. Visual grading found that genetics could explain between 46% and 71% of the variance.

Original languageEnglish
Title of host publicationMedical Imaging 2010
Subtitle of host publicationComputer-Aided Diagnosis
EditorsRonald M. Summers, Nico Karssemeijer
PublisherSPIE
ISBN (Electronic)9780819480255
DOIs
StatePublished - 2010
Externally publishedYes
EventMedical Imaging 2010: Computer-Aided Diagnosis - San Diego, United States
Duration: 16 Feb 201018 Feb 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7624
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2010: Computer-Aided Diagnosis
Country/TerritoryUnited States
CitySan Diego
Period16/02/1018/02/10

Keywords

  • age-related macular degeneration
  • amplitude-modulation
  • frequency-modulation
  • phenotyping

Fingerprint

Dive into the research topics of 'Toward automatic phenotyping of retinal images from genetically determined mono-and dizygotic twins using amplitude modulation-frequency modulation methods'. Together they form a unique fingerprint.

Cite this