Abstract
The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-O-tetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 μg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.
| Original language | English |
|---|---|
| Pages (from-to) | 79-84 |
| Number of pages | 6 |
| Journal | Skin Pharmacology and Applied Skin Physiology |
| Volume | 12 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 1999 |
| Externally published | Yes |
Keywords
- 12-O-tetradecanoylphorbol-13-acetate
- Anti-inflammatory activity
- Arachidonic acid
- Croton oil
- Epidermal growth factor
- Mice
- Psoriasis
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