Topical anti-inflammatory activity of human recombinant epidermal growth factor

A. Casacó Parada; N. Ledón; A. González; N. Merino; R. Pérez

doi:10.1159/000029848

Topical anti-inflammatory activity of human recombinant epidermal growth factor

A. Casacó Parada, N. Ledón, A. González, N. Merino, R. Pérez

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10 Scopus citations

Abstract

The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-O-tetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 μg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.

Original language	English
Pages (from-to)	79-84
Number of pages	6
Journal	Skin Pharmacology and Applied Skin Physiology
Volume	12
Issue number	1-2
DOIs	https://doi.org/10.1159/000029848
State	Published - 1999
Externally published	Yes

Keywords

12-O-tetradecanoylphorbol-13-acetate
Anti-inflammatory activity
Arachidonic acid
Croton oil
Epidermal growth factor
Mice
Psoriasis

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10.1159/000029848

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title = "Topical anti-inflammatory activity of human recombinant epidermal growth factor",

abstract = "The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-O-tetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 μg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.",

keywords = "12-O-tetradecanoylphorbol-13-acetate, Anti-inflammatory activity, Arachidonic acid, Croton oil, Epidermal growth factor, Mice, Psoriasis",

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doi = "10.1159/000029848",

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journal = "Skin Pharmacology and Applied Skin Physiology",

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T1 - Topical anti-inflammatory activity of human recombinant epidermal growth factor

AU - Casacó Parada, A.

AU - Ledón, N.

AU - González, A.

AU - Merino, N.

AU - Pérez, R.

PY - 1999

Y1 - 1999

N2 - The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-O-tetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 μg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.

AB - The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-O-tetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 μg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.

KW - 12-O-tetradecanoylphorbol-13-acetate

KW - Anti-inflammatory activity

KW - Arachidonic acid

KW - Croton oil

KW - Epidermal growth factor

KW - Mice

KW - Psoriasis

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DO - 10.1159/000029848

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SN - 1422-2868

VL - 12

SP - 79

EP - 84

JO - Skin Pharmacology and Applied Skin Physiology

JF - Skin Pharmacology and Applied Skin Physiology

IS - 1-2

ER -

Topical anti-inflammatory activity of human recombinant epidermal growth factor

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