TY - JOUR
T1 - Tau monoclonal antibody generation based on humanized yeast models
T2 - Impact on tau oligomerization and diagnostics
AU - Rosseels, Joëlle
AU - Van Den Brande, Jeff
AU - Violet, Marie
AU - Jacobs, Dirk
AU - Grognet, Pierre
AU - Lopez, Juan
AU - Huvent, Isabelle
AU - Caldara, Marina
AU - Swinnen, Erwin
AU - Papegaey, Anthony
AU - Caillierez, Raphaëlle
AU - Buée-Scherrer, Valerie
AU - Engelborghs, Sebastiaan
AU - Lippens, Guy
AU - Colin, Morvane
AU - Buée, Luc
AU - Galas, Marie Christine
AU - Vanmechelen, Eugeen
AU - Winderickx, Joris
N1 - Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
PY - 2015/2/13
Y1 - 2015/2/13
N2 - Background: Oligomers of protein Tau are associated with neurodegenerative diseases. Results: New antibodies were generated and validated that recognize different degrees of oligomerization of protein Tau. Conclusion: Low order and higher order oligomers differ in C-terminal Tau phosphorylation and reflect consecutive stages in disease progression. Significance: Antibodies recognizing Tau oligomers provide insight into disease etiology and are promising diagnostic tools.
AB - Background: Oligomers of protein Tau are associated with neurodegenerative diseases. Results: New antibodies were generated and validated that recognize different degrees of oligomerization of protein Tau. Conclusion: Low order and higher order oligomers differ in C-terminal Tau phosphorylation and reflect consecutive stages in disease progression. Significance: Antibodies recognizing Tau oligomers provide insight into disease etiology and are promising diagnostic tools.
UR - https://www.scopus.com/pages/publications/84922823517
U2 - 10.1074/jbc.M114.627919
DO - 10.1074/jbc.M114.627919
M3 - Article
C2 - 25540200
AN - SCOPUS:84922823517
SN - 0021-9258
VL - 290
SP - 4059
EP - 4074
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 7
ER -