Tau monoclonal antibody generation based on humanized yeast models: Impact on tau oligomerization and diagnostics

Joëlle Rosseels, Jeff Van Den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaëlle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie Christine Galas, Eugeen Vanmechelen, Joris Winderickx

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: Oligomers of protein Tau are associated with neurodegenerative diseases. Results: New antibodies were generated and validated that recognize different degrees of oligomerization of protein Tau. Conclusion: Low order and higher order oligomers differ in C-terminal Tau phosphorylation and reflect consecutive stages in disease progression. Significance: Antibodies recognizing Tau oligomers provide insight into disease etiology and are promising diagnostic tools.

Original languageEnglish
Pages (from-to)4059-4074
Number of pages16
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - 13 Feb 2015
Externally publishedYes

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