Tailoring size and release kinetics of κ/ι-hybrid carrageenan microgels via a surfactant-assisted technique

Sol Angel Rodriguez; F. G. Torres; Karen N. Gonzales; Omar P. Troncoso; Marta Fernández-García; Daniel Lopez

Tailoring size and release kinetics of κ/ι-hybrid carrageenan microgels via a surfactant-assisted technique

Sol Angel Rodriguez, F. G. Torres, Karen N. Gonzales, Omar P. Troncoso, Marta Fernández-García, Daniel Lopez

CSIC - Instituto de Ciencia y Tecnologia de Polimeros (ICTP)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

κ/ι-Hybrid carrageenan microgels were prepared to be used as drug delivery systems. A surfactant-assisted microemulsion technique was used. Tween® 80 was used as surfactant and enrofloxacin was used as a model drug. The results showed that the amount of surfactant used during processing determines the size of the microgels as well as the amount of enrofloxacin that can be loaded. At low surfactant content, the initial burst release effect is dominant whereas at high surfactant content the burst release effect is negligible and the Fickian diffusion mechanism is dominant.

Original language	Spanish
Pages (from-to)	338-344
Number of pages	7
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	70
State	Published - 1 Jan 2021

Cite this

@article{90a121fc4bea479bbebec7480229f421,

title = "Tailoring size and release kinetics of κ/ι-hybrid carrageenan microgels via a surfactant-assisted technique",

abstract = "κ/ι-Hybrid carrageenan microgels were prepared to be used as drug delivery systems. A surfactant-assisted microemulsion technique was used. Tween{\textregistered} 80 was used as surfactant and enrofloxacin was used as a model drug. The results showed that the amount of surfactant used during processing determines the size of the microgels as well as the amount of enrofloxacin that can be loaded. At low surfactant content, the initial burst release effect is dominant whereas at high surfactant content the burst release effect is negligible and the Fickian diffusion mechanism is dominant.",

author = "Rodriguez, {Sol Angel} and Torres, {F. G.} and Gonzales, {Karen N.} and Troncoso, {Omar P.} and Marta Fern{\'a}ndez-Garc{\'i}a and Daniel Lopez",

year = "2021",

month = jan,

day = "1",

language = "Espa{\~n}ol",

volume = "70",

pages = "338--344",

journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",

issn = "2574-0881",

}

TY - JOUR

T1 - Tailoring size and release kinetics of κ/ι-hybrid carrageenan microgels via a surfactant-assisted technique

AU - Rodriguez, Sol Angel

AU - Torres, F. G.

AU - Gonzales, Karen N.

AU - Troncoso, Omar P.

AU - Fernández-García, Marta

AU - Lopez, Daniel

PY - 2021/1/1

Y1 - 2021/1/1

N2 - κ/ι-Hybrid carrageenan microgels were prepared to be used as drug delivery systems. A surfactant-assisted microemulsion technique was used. Tween® 80 was used as surfactant and enrofloxacin was used as a model drug. The results showed that the amount of surfactant used during processing determines the size of the microgels as well as the amount of enrofloxacin that can be loaded. At low surfactant content, the initial burst release effect is dominant whereas at high surfactant content the burst release effect is negligible and the Fickian diffusion mechanism is dominant.

AB - κ/ι-Hybrid carrageenan microgels were prepared to be used as drug delivery systems. A surfactant-assisted microemulsion technique was used. Tween® 80 was used as surfactant and enrofloxacin was used as a model drug. The results showed that the amount of surfactant used during processing determines the size of the microgels as well as the amount of enrofloxacin that can be loaded. At low surfactant content, the initial burst release effect is dominant whereas at high surfactant content the burst release effect is negligible and the Fickian diffusion mechanism is dominant.

M3 - Artículo

SN - 2574-0881

VL - 70

SP - 338

EP - 344

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

ER -