Studies on the synthesis of di- and trisaccharide analogues of moenomycin A. Modifications in unit E and in the lipid part

Guangbin Yang, Madina Mansourova, Lothar Hennig, Matthias Findeisen, Ramona Oehme, Sabine Giesa, Peter Welzel

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2-4). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin-type transglycosylase inhibitors in detail and for preparing analogues with improved pharmacokinetic properties.

Original languageEnglish
Pages (from-to)1807-1824
Number of pages18
JournalHelvetica Chimica Acta
Volume87
Issue number7
DOIs
StatePublished - 2004
Externally publishedYes

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