Structure and estrogenic activity of new lignans from Iryanthera lancifolia

Dulce Mesa-Siverio; Rubén P. Machín; Ana Estévez-Braun; Ángel G. Ravelo; Olga Lock De Ugaz

Structure and estrogenic activity of new lignans from Iryanthera lancifolia

Dulce Mesa-Siverio
, Rubén P. Machín
, Ana Estévez-Braun
, Ángel G. Ravelo
, Olga Lock De Ugaz

Instituto Universitario de Bio-Orgánica Antonio González
Hospital Universitario Nuestra Senora de Candelaria
ICIC - Instituto Canario de Investigación del Cáncer
Pontificia Universidad Católica del Perú

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Five new dibenzylbutane type lignans (1-5) were isolated from the stem bark of Iryanthera lancifolia. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies and chemical evidence. Seventeen of the isolated compounds were tested for their estrogenic activities in the estrogen responsive human breast cancer cell line MCF-7 BUS using the E-Screen proliferation assay. Cell proliferation was evaluated by the SRB assay to calculate the estrogenic parameters. The majority of the compounds induced a mitogenic response. This effect, given as Relative Proliferative Effect (RPE) to reference estrogen 17β-estradiol (E2), ranged between 14% and 84%. © 2007 Elsevier Ltd. All rights reserved.

Original language	Spanish
Pages (from-to)	3387-3394
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	16
State	Published - 15 Mar 2008
Externally published	Yes

Cite this

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title = "Structure and estrogenic activity of new lignans from Iryanthera lancifolia",

abstract = "Five new dibenzylbutane type lignans (1-5) were isolated from the stem bark of Iryanthera lancifolia. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies and chemical evidence. Seventeen of the isolated compounds were tested for their estrogenic activities in the estrogen responsive human breast cancer cell line MCF-7 BUS using the E-Screen proliferation assay. Cell proliferation was evaluated by the SRB assay to calculate the estrogenic parameters. The majority of the compounds induced a mitogenic response. This effect, given as Relative Proliferative Effect (RPE) to reference estrogen 17β-estradiol (E2), ranged between 14\% and 84\%. {\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

author = "Dulce Mesa-Siverio and Mach{\'i}n, \{Rub{\'e}n P.\} and Ana Est{\'e}vez-Braun and Ravelo, \{{\'A}ngel G.\} and \{De Ugaz\}, \{Olga Lock\}",

year = "2008",

month = mar,

day = "15",

language = "Espa{\~n}ol",

volume = "16",

pages = "3387--3394",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

}

TY - JOUR

T1 - Structure and estrogenic activity of new lignans from Iryanthera lancifolia

AU - Mesa-Siverio, Dulce

AU - Machín, Rubén P.

AU - Estévez-Braun, Ana

AU - Ravelo, Ángel G.

AU - De Ugaz, Olga Lock

PY - 2008/3/15

Y1 - 2008/3/15

N2 - Five new dibenzylbutane type lignans (1-5) were isolated from the stem bark of Iryanthera lancifolia. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies and chemical evidence. Seventeen of the isolated compounds were tested for their estrogenic activities in the estrogen responsive human breast cancer cell line MCF-7 BUS using the E-Screen proliferation assay. Cell proliferation was evaluated by the SRB assay to calculate the estrogenic parameters. The majority of the compounds induced a mitogenic response. This effect, given as Relative Proliferative Effect (RPE) to reference estrogen 17β-estradiol (E2), ranged between 14% and 84%. © 2007 Elsevier Ltd. All rights reserved.

AB - Five new dibenzylbutane type lignans (1-5) were isolated from the stem bark of Iryanthera lancifolia. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies and chemical evidence. Seventeen of the isolated compounds were tested for their estrogenic activities in the estrogen responsive human breast cancer cell line MCF-7 BUS using the E-Screen proliferation assay. Cell proliferation was evaluated by the SRB assay to calculate the estrogenic parameters. The majority of the compounds induced a mitogenic response. This effect, given as Relative Proliferative Effect (RPE) to reference estrogen 17β-estradiol (E2), ranged between 14% and 84%. © 2007 Elsevier Ltd. All rights reserved.

M3 - Artículo

SN - 0968-0896

VL - 16

SP - 3387

EP - 3394

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

ER -