Síntesis, caracterización y estudio cinético de liberación de nanopartículas de almidón cargadas con enrofloxacina

Translated title of the contribution: Synthesis, characterization and release kinetic evaluation of starch nanoparticles loaded with enrofloxacin

Eduardo Yupanqui, Sol Angel Rodriguez, Marly P. Alvites

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Starch is a natural polysaccharide, versatile and widely available thanks to various native products of Peru, which can be used for the development of new engineering materials. In recent years, starch nanoparticles have been proposed as promising materials for the development of new pharmaceuticals, nutraceuticals or reinforcements (fillers). Hence, the objective of this research is to produce starch nanoparticles from Peruvian potato starches for transport and drug delivery, using enrofloxacin (ENX) as a model drug. Starch nanoparticles were obtained using a flash-nanoprecipitation. Tween®80 was used as a surfactant and sodium tripolyphosphate (STPP) as a crosslinking agent. After the elaboration, all the systems were characterized with various morphological, structural and thermal tests, as well as the encapsulation capacity and drug release of the systems were studied. As a result, the size of the starch nanoparticles was in the range of 10 to 150 nm in diameter, while the sizes of ENX-loaded starch nanoparticles range between 60 and 240 nm. However, no relationship was observed between the variants of potato starch and the characteristics of the starch nanoparticles systems. In all cases, it was shown that the release of ENX is dominated by Fickian diffusive phenomena. In conclusion, the results indicate that starch particles could be considered good alternatives for the preparation of excipients due to the ease of preparation and the possibility of controlling the release kinetics of drugs and active substances.

Translated title of the contributionSynthesis, characterization and release kinetic evaluation of starch nanoparticles loaded with enrofloxacin
Original languageSpanish
Title of host publicationProceedings of the 22nd LACCEI International Multi-Conference for Engineering, Education and Technology
Subtitle of host publicationSustainable Engineering for a Diverse, Equitable, and Inclusive Future at the Service of Education, Research, and Industry for a Society 5.0., LACCEI 2024
PublisherLatin American and Caribbean Consortium of Engineering Institutions
ISBN (Electronic)9786289520781
DOIs
StatePublished - 2024
Externally publishedYes
Event22nd LACCEI International Multi-Conference for Engineering, Education and Technology, LACCEI 2024 - Hybrid, San Jose, Costa Rica
Duration: 17 Jul 202419 Jul 2024

Publication series

NameProceedings of the LACCEI international Multi-conference for Engineering, Education and Technology
ISSN (Electronic)2414-6390

Conference

Conference22nd LACCEI International Multi-Conference for Engineering, Education and Technology, LACCEI 2024
Country/TerritoryCosta Rica
CityHybrid, San Jose
Period17/07/2419/07/24

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