Immunopotentiating properties of a multispecific α-anti-idiotype antibody

Tays Hernández; Cristina Mateo De Acosta; Rolando Pérez

doi:10.4161/mabs.19872

Immunopotentiating properties of a multispecific α-anti-idiotype antibody

Tays Hernández, Cristina Mateo De Acosta, Rolando Pérez

National School of Public Health

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Multispecificity is not a well-understood property of some antibodies. Different functions have been attributed to multispecific natural antibodies, commonly associated with the neutralization and clearance of antigens. Much less is known about the role of antibodies like these, based on their idiotypic connectivity. B7Y33 is a chimeric IgG1 version of a polyreactive α anti-idiotype antibody that is able to interact with different immunoglobulin and non-immunoglobulin antigens. Here we report the capacity of this antibody to enhance the immunogenicity of several autologous IgMs in adjuvant-free conditions. Our results suggest that the formation of immune complexes seems to be necessary, but not sufficient, to this activity. The potential involvement of the interaction of B7Y33 with the FcγRII b is discussed.

Original language	English
Pages (from-to)	398-402
Number of pages	5
Journal	mAbs
Volume	4
Issue number	3
DOIs	https://doi.org/10.4161/mabs.19872
State	Published - May 2012
Externally published	Yes

Keywords

FcγRIIb
Immune complexes
Immunogenicity
Multispecific antibody
Multispecificity

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10.4161/mabs.19872

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abstract = "Multispecificity is not a well-understood property of some antibodies. Different functions have been attributed to multispecific natural antibodies, commonly associated with the neutralization and clearance of antigens. Much less is known about the role of antibodies like these, based on their idiotypic connectivity. B7Y33 is a chimeric IgG1 version of a polyreactive α anti-idiotype antibody that is able to interact with different immunoglobulin and non-immunoglobulin antigens. Here we report the capacity of this antibody to enhance the immunogenicity of several autologous IgMs in adjuvant-free conditions. Our results suggest that the formation of immune complexes seems to be necessary, but not sufficient, to this activity. The potential involvement of the interaction of B7Y33 with the FcγRII b is discussed.",

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AB - Multispecificity is not a well-understood property of some antibodies. Different functions have been attributed to multispecific natural antibodies, commonly associated with the neutralization and clearance of antigens. Much less is known about the role of antibodies like these, based on their idiotypic connectivity. B7Y33 is a chimeric IgG1 version of a polyreactive α anti-idiotype antibody that is able to interact with different immunoglobulin and non-immunoglobulin antigens. Here we report the capacity of this antibody to enhance the immunogenicity of several autologous IgMs in adjuvant-free conditions. Our results suggest that the formation of immune complexes seems to be necessary, but not sufficient, to this activity. The potential involvement of the interaction of B7Y33 with the FcγRII b is discussed.

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Immunopotentiating properties of a multispecific α-anti-idiotype antibody

Abstract

Keywords

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