TY - JOUR
T1 - Immunogenicity of autologous immunoglobulins
T2 - Principles and practices
AU - López-Requena, Alejandro
AU - Mateo De Acosta, Cristina
AU - Vázquez, Ana María
AU - Pérez, Rolando
PY - 2007/4
Y1 - 2007/4
N2 - The immunogenicity of immunoglobulin idiotypes in syngeneic systems is a rather rare phenomenon. Very few studies have attempted to determine the mechanisms underlying the anti-idiotypic response that certain autologous idiotypes can elicit. Furthermore, the studies addressing a possible physiological role for such behaviors are even less. In the present article, the results of the characterization of a highly immunogenic idiotype are reviewed and compared with some related works on the subject. We finally propose a possible immunoregulatory role for idiotypic immunogenicity.
AB - The immunogenicity of immunoglobulin idiotypes in syngeneic systems is a rather rare phenomenon. Very few studies have attempted to determine the mechanisms underlying the anti-idiotypic response that certain autologous idiotypes can elicit. Furthermore, the studies addressing a possible physiological role for such behaviors are even less. In the present article, the results of the characterization of a highly immunogenic idiotype are reviewed and compared with some related works on the subject. We finally propose a possible immunoregulatory role for idiotypic immunogenicity.
KW - Anti-idiotypic antibodies
KW - Autoimmunogenicity
KW - Autologous immunoglobulins
KW - Idiotype
UR - http://www.scopus.com/inward/record.url?scp=33947125995&partnerID=8YFLogxK
U2 - 10.1016/j.molimm.2007.01.005
DO - 10.1016/j.molimm.2007.01.005
M3 - Comment/debate
C2 - 17306373
AN - SCOPUS:33947125995
SN - 0161-5890
VL - 44
SP - 3076
EP - 3082
JO - Molecular Immunology
JF - Molecular Immunology
IS - 11
ER -