Epidermal growth factor receptors in human breast cancer

Rolando Pérez; María Pascual; Amparo Macías; Agustín Lage

doi:10.1007/BF01806484

Epidermal growth factor receptors in human breast cancer

Rolando Pérez, María Pascual, Amparo Macías, Agustín Lage

Instituto Nacional de Oncologia y Radiobiologia, Havana, cu

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

The capacity for specific binding of¹²⁵I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.

Original language	English
Pages (from-to)	189-193
Number of pages	5
Journal	Breast Cancer Research and Treatment
Volume	4
Issue number	3
DOIs	https://doi.org/10.1007/BF01806484
State	Published - Sep 1984
Externally published	Yes

Keywords

breast cancer
EGF receptor
estrogen receptor
growth factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF01806484

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title = "Epidermal growth factor receptors in human breast cancer",

abstract = "The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.",

keywords = "breast cancer, EGF receptor, estrogen receptor, growth factors",

author = "Rolando P{\'e}rez and Mar{\'i}a Pascual and Amparo Mac{\'i}as and Agust{\'i}n Lage",

year = "1984",

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doi = "10.1007/BF01806484",

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AU - Pérez, Rolando

AU - Pascual, María

AU - Macías, Amparo

AU - Lage, Agustín

PY - 1984/9

Y1 - 1984/9

N2 - The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.

AB - The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.

KW - breast cancer

KW - EGF receptor

KW - estrogen receptor

KW - growth factors

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DO - 10.1007/BF01806484

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SP - 189

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JF - Breast Cancer Research and Treatment

IS - 3

ER -

Epidermal growth factor receptors in human breast cancer

Abstract

Keywords

UN SDGs

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