Development of an Intervertebral Disc for Cervical Spondylosis Composed of Seeded Biomaterials

Mariana Vasquez-Alvarez, Uriel Zapata, Fanny L. Casado

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Most of the current artificial disc prosthesis presented a restricted range of motion. Here we propose the design of a novel intervertebral disc composed of carbon fiber, hyaluronic methylcellulose hydrogel loaded with mesenchymal stem cells and polycaprolactone. The prosthesis was biomechanically evaluated under two static physiological conditions to study the mechanical influence of the material on the device. The results obtained in the simulations showed a not only a congruent behavior with preclinical condition, but also that the proposed materials met the desired biomechanical properties Clinical Relevance- Cervical spondylosis is a degenerative disease of the human spine that causes wear and tear of the cervical intervertebral discs. Nowadays, the proposed surgical solutions do not allow fully recovery of normal movement because the surgical intervention do not emulate the natural range of motion, may lack shock absorption mechanisms, show signs of fatigue over time affecting its durability, and do not have good bone adhesion. Therefore, hypermobility and problems of heterotopic ossification may restrict the range of motion.

Original languageEnglish
Title of host publication44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3931-3934
Number of pages4
ISBN (Electronic)9781728127828
DOIs
StatePublished - 2022
Event44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022 - Glasgow, United Kingdom
Duration: 11 Jul 202215 Jul 2022

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2022-July
ISSN (Print)1557-170X

Conference

Conference44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
Country/TerritoryUnited Kingdom
CityGlasgow
Period11/07/2215/07/22

Keywords

  • Biomaterial-cell interactions
  • Fabrication of cell seeded scaffolds
  • Functional biomaterials
  • Osseointegration
  • Scaffolds in tissue engineering
  • Translational issues in tissue engineering and biomaterials

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