Constituents of Werneria ciliolata and their in vitro anti-hiv activity

Sonia Piacente, Rita Aquino, Nunziatina De Tommasi, Cosimo Pizza, Olga Lock de Ugaz, Day'dee Chavez Orellana, Naheed Mahmood

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29 Scopus citations


The aerial part of Werneria ciliolata afforded a series of new diterpenes: two ent-kaurane derivatives, a nor-kaurane, an ent-manoyloxide derivative, a dimeric diterpene, as well as a rare diterpene. Their structures were elucidated by spectroscopic methods, including the concerted application of 1D NMR techniques (DEPT and NOEDS) and 2D NMR techniques (1H-1H COSY and HETCOR). In addition, four known kauranes, four coumarins and 6-hydroxytremetone were isolated. All isolated compounds from W. ciliolata and W. dactylophylla were tested in vitro for anti-viral activity against HIV-1, but only 6-hydroxytremetone showed a significant anti-HIV-1 activity. © 1994.
Original languageSpanish
Pages (from-to)991-996
Number of pages6
StatePublished - 1 Jan 1994
Externally publishedYes

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