Anti-Idiotypic Antibodies

Alejandro López-Requena; Oscar Roberto Burrone; Rolando Pérez

doi:10.1002/9783527682423.ch16

Anti-Idiotypic Antibodies

Alejandro López-Requena, Oscar Roberto Burrone, Rolando Pérez

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

An antibody specific for the variable regions, or idiotype, of another antibody (Ab1) is termed anti-idiotypic antibody (Ab2). The Idiotypic Network is one of the most polemic theories in the field of Immunology. Nevertheless, naturally occurring anti-idiotypic antibodies have been associated with the progression or control of some pathological conditions. The most exploited property of anti-idiotypic antibodies is their ability to mimic antigens of diverse chemical nature. Thus, immunization with an Ab2 generated against an Ab1 specific for a given antigen may elicit an immune response specific for the antigen. Vaccine formulations based on anti-idiotypic antibodies have been assayed for the treatment of cancer and other diseases.

Original language	English
Title of host publication	Defining the Right Antibody Composition
Publisher	Wiley-Blackwell
Pages	407-434
Number of pages	28
Volume	1-4
ISBN (Electronic)	9783527682423
ISBN (Print)	9783527329373
DOIs	https://doi.org/10.1002/9783527682423.ch16
State	Published - 3 Dec 2014
Externally published	Yes

Keywords

Ab2
Anti-idiotypic antibody
Anti-idiotypic vaccine
Antigen mimicry
Idiotype
Internal image

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/9783527682423.ch16

Cite this

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title = "Anti-Idiotypic Antibodies",

abstract = "An antibody specific for the variable regions, or idiotype, of another antibody (Ab1) is termed anti-idiotypic antibody (Ab2). The Idiotypic Network is one of the most polemic theories in the field of Immunology. Nevertheless, naturally occurring anti-idiotypic antibodies have been associated with the progression or control of some pathological conditions. The most exploited property of anti-idiotypic antibodies is their ability to mimic antigens of diverse chemical nature. Thus, immunization with an Ab2 generated against an Ab1 specific for a given antigen may elicit an immune response specific for the antigen. Vaccine formulations based on anti-idiotypic antibodies have been assayed for the treatment of cancer and other diseases.",

keywords = "Ab2, Anti-idiotypic antibody, Anti-idiotypic vaccine, Antigen mimicry, Idiotype, Internal image",

author = "Alejandro L{\'o}pez-Requena and Burrone, \{Oscar Roberto\} and Rolando P{\'e}rez",

year = "2014",

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doi = "10.1002/9783527682423.ch16",

language = "English",

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volume = "1-4",

pages = "407--434",

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TY - CHAP

T1 - Anti-Idiotypic Antibodies

AU - López-Requena, Alejandro

AU - Burrone, Oscar Roberto

AU - Pérez, Rolando

PY - 2014/12/3

Y1 - 2014/12/3

N2 - An antibody specific for the variable regions, or idiotype, of another antibody (Ab1) is termed anti-idiotypic antibody (Ab2). The Idiotypic Network is one of the most polemic theories in the field of Immunology. Nevertheless, naturally occurring anti-idiotypic antibodies have been associated with the progression or control of some pathological conditions. The most exploited property of anti-idiotypic antibodies is their ability to mimic antigens of diverse chemical nature. Thus, immunization with an Ab2 generated against an Ab1 specific for a given antigen may elicit an immune response specific for the antigen. Vaccine formulations based on anti-idiotypic antibodies have been assayed for the treatment of cancer and other diseases.

AB - An antibody specific for the variable regions, or idiotype, of another antibody (Ab1) is termed anti-idiotypic antibody (Ab2). The Idiotypic Network is one of the most polemic theories in the field of Immunology. Nevertheless, naturally occurring anti-idiotypic antibodies have been associated with the progression or control of some pathological conditions. The most exploited property of anti-idiotypic antibodies is their ability to mimic antigens of diverse chemical nature. Thus, immunization with an Ab2 generated against an Ab1 specific for a given antigen may elicit an immune response specific for the antigen. Vaccine formulations based on anti-idiotypic antibodies have been assayed for the treatment of cancer and other diseases.

KW - Ab2

KW - Anti-idiotypic antibody

KW - Anti-idiotypic vaccine

KW - Antigen mimicry

KW - Idiotype

KW - Internal image

UR - https://www.scopus.com/pages/publications/84940830868

U2 - 10.1002/9783527682423.ch16

DO - 10.1002/9783527682423.ch16

M3 - Chapter

AN - SCOPUS:84940830868

SN - 9783527329373

VL - 1-4

SP - 407

EP - 434

BT - Defining the Right Antibody Composition

PB - Wiley-Blackwell

ER -

Anti-Idiotypic Antibodies

Abstract

Keywords

UN SDGs

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