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Item type:Publication, Fast High Resolution Blood Flow Estimation and Clutter Rejection via an Alternating Optimization Problem(Cornell University, 2020-11-03)This paper introduces a computationally efficient technique for estimating high-resolution Doppler blood flow from an ultrafast ultrasound image sequence. More precisely, it consists in a new fast alternating minimization algorithm that implements a blind deconvolution method based on robust principal component analysis. Numerical investigation carried out on \textit{in vivo} data shows the efficiency of the proposed approach in comparison with state-of-the-art methods. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Applications of microarrays for mass spectrometry (MAMS) in single-cell metabolomics(Humana Press Inc.humana@humanapr.com, 2020-01-01)The metabolic network is the endpoint in the flow of information that begins with the “gene” and ends with “phenotype” (observable function) of the cell. Previously, due to the variety of metabolites analyzed inside cells, the metabolomic measurements were performed with samples including multiple cells. Unfortunately, this sampling process may mask important metabolic phenomena, such as cell-to-cell heterogeneity. For these studies, we must use analytical techniques that can robustly deliver reproducible results with single-cell sensitivity. In this chapter, we summarize laser-based methods for single-cell analysis and a novel approach of MicroArrays for Mass Spectrometry (or MAMS) is described in full detail. This particular type of microarrays was tailored for the study of cells grown in liquid medium using multiple-analytical read-outs, such as optical and laser desorption/ionization (LDI) or MALDI mass spectrometry.1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Supernova Neutrino Burst Detection with the Deep Underground Neutrino Experiment(White Rose University Consortium, 2020-08-15)Abstract: The Deep Underground Neutrino Experiment (DUNE), a 40-kton underground liquid argon time projection chamber experiment, will be sensitive to the electron-neutrino flavor component of the burst of neutrinos expected from the next Galactic core-collapse supernova. Such an observation will bring unique insight into the astrophysics of core collapse as well as into the properties of neutrinos. The general capabilities of DUNE for neutrino detection in the relevant few- to few-tens-of-MeV neutrino energy range will be described. As an example, DUNE’s ability to constrain the νe spectral parameters of the neutrino burst will be considered. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Professional trajectories of women teachers in the engineering area of a private university in Peru(2020-09-30)The aim of this study was to analyze the perceptions of women engineering teachers about their professional trajectories. Regarding the methodology, the qualitative approach and the phenomenological method were chosen. In addition, six female teachers of the engineering area were interviewed. The main findings indicated that the motivations to redirect their professional path towards teaching were the acknowledgments, the promotion of research and schedules' flexibility, despite not considering it as the first option of professional development. Also, teaching provided them with opportunities to pursue graduate studies without restrictions, to care for their families and to postpone motherhood. However, working at a university meant facing organizational obstacles, such as differences in treatment according to gender and age, as well as practices of exclusion and favoritism. - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Prospects for beyond the Standard Model physics searches at the Deep Underground Neutrino Experiment(White Rose University Consortium, 2020-11-10)Abstract: The Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM). Of the many potential beyond the Standard Model (BSM) topics DUNE will probe, this paper presents a selection of studies quantifying DUNE’s sensitivities to sterile neutrino mixing, heavy neutral leptons, non-standard interactions, CPT symmetry violation, Lorentz invariance violation, neutrino trident production, dark matter from both beam induced and cosmogenic sources, baryon number violation, and other new physics topics that complement those at high-energy colliders and significantly extend the present reach. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume II: DUNE Physics(U.S. Department of Energy / OSTI, 2020-02-07)The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume II of this TDR, DUNE Physics, describes the array of identified scientific opportunities and key goals. Crucially, we also report our best current understanding of the capability of DUNE to realize these goals, along with the detailed arguments and investigations on which this understanding is based. This TDR volume documents the scientific basis underlying the conception and design of the LBNF/DUNE experimental configurations. As a result, the description of DUNE's experimental capabilities constitutes the bulk of the document. Key linkages between requirements for successful execution of the physics program and primary specifications of the experimental configurations are drawn and summarized. This document also serves a wider purpose as a statement on the scientific potential of DUNE as a central component within a global program of frontier theoretical and experimental particle physics research. Thus, the presentation also aims to serve as a resource for the particle physics community at large.2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Local experiences of mining in Peru: Social and spatial transformations in the Andes(Taylor and Francis, 2020-02-20)This book uses a multimethod approach to examine local experience of contemporary mining development in the Peruvian Andes, creating an understanding of the transformations that rural societies experience in this context. Mining is a major component of economic growth in many resource endowed countries, whilst also causing mixed social, cultural, and environmental effects. Most current literature on contemporary mining in Peru is largely focussed on conflict; however, in this text, the author takes a differing approach by examining the experiences of families in the vicinity of Rio Tinto's La Granja exploration copper project, Northern Peru, an area with great significance due to the mining investment and development, which has taken place over the past 25 years. The book first provides a critical discussion about production of space theories, and debates on spatial mobility, highlighting their relevance to understanding large-scale mining developments, especially in the Peruvian Andes. The following chapters analyze spatial transformations mining development has prompted, focusing on four axes: access to space, production, mobility, and representations of space. A comprehensive narrative is constructed drawing on diverse voices and perspectives, including those of family heads and their partners, local leaders, company employees, and social scientists. The book concludes by discussing how the findings challenge some of the current accounts of the social effects of mining developement on rural communities and pose significant implications for sustainable development programs and place-based practices. By taking an interdisciplinary approach, this book will appeal to a wide audience including geographers, social anthropologists, and social scientists interested in the social effects of mining as well as researchers interested in current Latin American Studies and Rural Development.